Jonathan D. Gough 
Assistant Professor 
Organic Chemistry

CONTACT INFORMATION

Office:      M601

Telephone:    (718) 488-1663

E-mail:     Jonathan.Gough@liu.edu

EDUCATION

Postdoctoral Fellowship:    Yale University, Newhaven, CT, with Craig Crews

Ph.D., Bioorganic Chemistry:     Syracuse University, Syracuse, NY

B.S., Chemistry:     Eastern Nazarene College, Quincy, MA

PUBLICATIONS

  1. Jonathan D. Gough, Craig M. Crews, "Using Natural Products to Unravel Cell Biology", Book Chapter in Chemical Biology: From Small Molecules to Systems Biology and Drug Design. Wiley Press, 2007
  2. Jonathan D. Gough, Craig M. Crews, "Probing Protein Function with Small Molecules." Ernst Schering Research Foundation Workshop. Chemical Genomics, 2005. 58, 61-74.
  3. Jonathan D. Gough and Watson J. Lees, "ortho-and meta-Substituted Aromatic Thiols as Efficient Redox Buffer for Increasing the Folding Rate of a Disulfide Containing Protein" Journal of Biotechnology, 2005. 125, 39-47.
  4. Jonathan D. Gough and Watson J. Lees, "Increased Catalytic Activity of Protein Disulfide Isomerase (PDI) in the Presence of Aromatic Thiol Based Redox Buffers" Bioorganic Medicinal Chemistry Letters, 2005. 15, 777-781.
  5. Jonathan D. Gough and Watson J. Lees, "Effects of Redox Buffer Properties on the Folding of a Disulfide Containing Protein: Dependence upon pH, Thiol pKa, and Thiol Concentration", Journal of Biotechnology, 2005. 115, 279-290.
  6. Jonathan D. Gough, Joseph M. Gargano, Anthony E. Donofrio, and Watson J. Lees, ", Aromatic Thiol pKa Effects on the Folding Rate of a Disulfide Containing Protein" Biochemistry, 2003. 42, 11787-11797.
  7. Jonathan D. Gough, Rhondye H. Williams, Jr., Anthony E. Donofrio, and Watson J. Lees, "Folding Disulfide-Containing Proteins Faster with an Aromatic Thiol" Journal of the American Chemical Society, 2002. 124, 3885-3892.
  8. Hassan Musa, Jonathan D. Gough, Watson J. Lees, and Richard D. Veenstra, "Ionic Blockade of the Rat Connexin40 Gap Junction Channel by Large Tetraalkylammonium Ions" Biophysical Journal, 2001. 81, 3253-3274.
  9. Jonathan D. Gough, and Lowell H. Hall, "Modeling Antileukemic Activity of Carboquinones with Electrotopological State and Chi Indices" Journal of Chemical Information and Computer Sciences, 1999. 39, 356-361.
  10. . Jonathan D. Gough, and Lowell H. Hall, "Modeling the Toxicity of Amide Herbicides Using the Electrotopological State" Environmental Toxicology and Chemistry, 1999. 18, 1069-1075.

 

COURSES TAUGHT